The Psilocybin Business Guide

The business of mushrooms
is opening up.

Colorado, Oregon, Michigan and more are decriminalizing and legalizing psilocybin. Be ready when your state does too. We have the guides.

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Explore

Everything you need to know.

Guides, state-by-state breakdowns, and the fundamentals — all in one place.

🍁
Start a Dispensary

The complete step-by-step guide to opening a psilocybin healing center or dispensary.

Read the guide →
🏔
Colorado

Prop 122 made Colorado the most open state for psilocybin entrepreneurs. Here's how to operate there.

Colorado guide →
🌳
Oregon

Oregon's Measure 109 built the nation's first psilocybin service center framework. The model for every state.

Oregon guide →
🌎
Decriminalized Cities

Denver, Ann Arbor, Oakland, Seattle, DC and more. Decrim is always step one — see what's next.

See all cities →
🔬
What is Psilocybin?

The business owner's primer. What it is, what the science says, and why the market is real.

Read the primer →
Colorado Decriminalized & Licensed Oregon Therapeutic Use Legal Michigan Decriminalized in Several Cities More States Coming
Why Now

The window is open.

The legal landscape is shifting fast. The entrepreneurs who move now will own the market.

Colorado

Prop 122 Passed

Colorado legalized personal use and licensed healing centers in 2022. The first licensed facilities are now open. The framework exists. You can build in it.

Oregon

Measure 109

Oregon created a full regulated therapeutic psilocybin framework. Licensed facilitators and service centers are operating. The model for the country.

Michigan / DC / More

Decrim Wave

Ann Arbor, Detroit, Denver, Seattle, Oakland, Washington DC have all decriminalized. Decrim is step one. Legalization follows. It always does.

Federal

FDA Breakthrough Therapy

Psilocybin holds FDA Breakthrough Therapy designation for depression. Federal rescheduling is a matter of when, not if. This is the cannabis story, again.

The Guides

Start building your business today.

Practical, actionable guides written for entrepreneurs — not lawyers or academics.

$77 — Starter Guide

How to Start a Psilocybin Business

The essential roadmap for first-time operators. Understand the legal landscape in your state, choose the right business model, and take your first steps.

  • State-by-state legal status overview
  • Business structures that work
  • Licensing requirements & timelines
  • Finding your location & space
  • Funding your operation
  • Compliance basics
Get the Starter Guide — $77
$297 — Complete Package

The Complete Psilocybin Business Library

Every guide we publish, in one package. Everything you need from first concept to open doors — plus all future guides at no extra cost.

  • All starter guide content
  • Advanced compliance & legal guide
  • Cultivation & sourcing guide
  • Marketing & community building
  • Financial modeling & projections
  • Hiring & training facilitators
  • All future guides included free
Get the Complete Package — $297
Amadeus Voss, Founder of Mushroom University
About the Author

Amadeus Voss

“I watched the cannabis industry go from criminal to billion-dollar in fifteen years. Psilocybin is on the same track. The difference is you can see it coming this time.”

Amadeus Voss spent two decades building one of the most successful cannabis dispensary networks in the American West. After selling his portfolio, he stepped back from the industry entirely and onto his yacht. Today he’s focused on what he believes is the next major shift in alternative medicine and entrepreneurship: psilocybin. Mushroom University is where he shares what he knows.

20+
Years in the industry
8-fig
Dispensary portfolio exit
12
States operated in
From Amadeus Voss

Laws are changing weekly.

Get free updates from Amadeus when new states decriminalize or legalize, plus early access to new guides.